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Grape (Vitis vinifera)

Grape (Vitis vinifera)

(Vitis vinifera)

Use(s) or Purpose(s)

  • Used for preventing cardiovascular disease, varicose veins, hemorrhoids, atherosclerosis, hypertension, peripheral vascular disease, edema associated with injury or surgery, and myocardial or cerebral infarction.
  • Used and as a mild laxative for constipation. Grape "fasts" have been used for "detoxification."
  • Used for diabetes complications such as neuropathy or retinopathy, improving wound healing, preventing dental caries, cancer prevention, age-related macular degeneration (ARMD), poor night vision, liver cirrhosis, allergic rhinitis, and prevention of collagen breakdown.
  • Used orally for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine hemorrhage, and canker sores.

Risks Information

Caution(s) and Warning(s)
No statement is required

Grape juice is thought to induce cytochrome P450 1A2 (CYP1A2) metabolism and may decrease plasma levels of CYP1A2 substrates. Drugs metabolized by CYP1A2 include amitriptyline (Elavil), caffeine, chlordiazepoxide (Librium), clomipramine (Anafranil), clopidogrel (Plavix), clozapine (Clozaril), cyclobenzaprine (Flexaril), desipramine (Norpramin), diazepam (Valium), estradiol (Estrace, others), flutamide (Eulexin), fluvoxamine (Luvox), grepafloxacin (Raxar), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), mirtazapine (Remeron), naproxen (Naprosyn), nortriptyline (Pamelor), olanzapine (Zyprexa), ondansetron (Zofran), propafenone (Rythmol), propranolol (Inderal), riluzole (Rilutek), ropinirole (Requip), ropivacaine (Naropin), tacrine (Cognex), theophylline (Theo-Dur, others), verapamil (Calan, Covera-HS, others), warfarin (Coumadin), and zileuton (Zyflo).
Grape juice decreases phenacetin, but not acetaminophen plasma levels. It may decrease levels by inducing cytochrome P450 1A2 (CYP1A2) metabolism.
Theoretically, due to the tocopherol content of grape seed oil, concomitant use with warfarin might increase warfarin's effects and the risk of bleeding; use with caution.
LACTOBACILLUS ACIDOPHILUS: Grape anthocyanins might inhibit the growth of Lactobacillus acidophilus. Theoretically, concurrent administration might prevent Lactobacillus acidophilus colonization of the gastrointestinal tract; avoid concurrent use.
VITAMIN C: Preliminary evidence suggests that patients with hypertension who take both vitamin C 500 mg/day plus grape seed polyphenols 1000 mg/day have significantly increased systolic and diastolic blood pressure. The potential mechanism of this interaction is not known.

Known Adverse Reaction(s)
Orally, grape seed extract is well tolerated. Headache, abdominal pain, sore throat, nausea, and cough have been reported with used of grape seed, but these effects occur at rates similar to placebo.
Excessive consumption of grapes, dried grapes, raisins, or sultanas might cause diarrhea due to laxative effects.
There is one report of an anaphylactic reaction to grape skin extract, which included urticaria and angioedema.
Grape leaves have been reported to cause gastrointestinal discomfort, diarrhea, dyspepsia, dry mouth, and retching. Other adverse effects included infections, headache, and musculoskeletal disorders. One case of leg hematoma following a minor trauma was also reported in a person using grape leaf extract.

We find grape in:

Green Tea     


References :
Natural Medicines Comprehensive Database.
Google Images.
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